Table 1.
Baseline demographics and characteristics of patients in REGAIN
| Eculizumab (n = 62) | Placebo (n = 63) | |
|---|---|---|
| Age at diagnosis, years, mean (SD) | 38.0 (17.8) | 38.1 (19.6) |
| Age at first study dose, years, mean (SD) | 47.5 (15.7) | 46.9 (18.0) |
| Sex, n (%) | ||
| Male | 21 (34%) | 22 (35%) |
| Female | 41 (66%) | 41 (65%) |
| Race, n (%) | ||
| Asian | 3 (5%) | 16 (25%) |
| Black or African American | 0 | 3 (5%) |
| White | 53 (85%) | 42 (67%) |
| Other | 6 (10%) | 2 (3%) |
| BMI, kg/m2, mean (SD) | 31.4 (9.0) | 30.5 (8.4) |
| Myasthenia gravis duration, years, mean (SD) | 9.9 (8.1) | 9.2 (8.4) |
| Neuro-QOL Fatigue total score, mean (SD); mediana | 64.1 (14.1); 64.0 | 61.8 (15.9); 64.0 |
| Neuro-QOL Fatigue item score, mean (SD); mediana | ||
| I felt exhausted | 3.6 (0.82); 4.0 | 3.5 (1.09); 4.0 |
| I felt that I had no energy | 3.7 (1.04); 4.0 | 3.7 (0.98); 4.0 |
| I felt fatigued | 3.8 (0.88); 4.0 | 3.7 (0.91); 4.0 |
| I was too tired to do my household chores | 3.5 (1.01); 4.0 | 3.3 (1.03); 3.0 |
| I was too tired to leave the house | 3.2 (1.01); 3.0 | 3.2 (0.99); 3.0 |
| I was frustrated by being too tired to do the things I wanted to do | 3.7 (1.08); 4.0 | 3.4 (1.21); 3.0 |
| I felt tired | 3.8 (0.80); 4.0 | 3.8 (0.97); 4.0 |
| I had to limit my social activity because I was tired | 3.6 (1.00); 4.0 | 3.4 (1.13); 4.0 |
| I needed help doing my usual activities because of my fatigue | 3.0 (1.24); 3.0 | 2.9 (1.22); 3.0 |
| I needed to sleep during the day | 3.3 (1.29); 3.0 | 3.4 (1.23); 4.0 |
| I had trouble starting things because I was too tired | 3.3 (0.89); 3.0 | 3.1 (1.13); 3.0 |
| I had trouble finishing things because I was too tired | 3.5 (0.99); 4.0 | 3.2 (1.06); 3.0 |
| I was too tired to take a short walk | 3.4 (1.19); 4.0 | 3.1 (1.29); 3.0 |
| I was too tired to eat | 2.6 (1.07); 3.0 | 2.3 (1.09); 2.0 |
| I was so tired that I had to rest during the day | 3.7 (1.06); 4.0 | 3.6 (1.07); 4.0 |
| I felt weak all over | 3.3 (1.07); 3.0 | 3.3 (1.13); 3.0 |
| I needed help doing my usual activities because of weakness | 2.9 (1.24); 3.0 | 2.9 (1.18); 3.0 |
| I had to limit my social activity because I was physically weak | 3.3 (1.23); 3.0 | 3.3 (1.04); 3.0 |
| I had to force myself to get up and do things because I was physically too weak | 3.0 (1.18); 3.0 | 2.9 (1.17); 3.0 |
SD standard deviation
aSome patients did not complete all items of the questionnaire. When this occurred, total scores could not be computed and the specific item score is missing for those patients