Figure 8. Regulatory mechanism by which miR-613 mediated migration, invasion, and angiogenesis in NPC via the AKT signaling pathway by regulating FN1.

miR-613 overexpression and FN1 silencing inactivated the AKT signaling pathway to inhibit invasion, migration, and angiogenesis in NPC, corresponding to down-regulated Bcl-2, MMP-2, MMP-9, VEGF, and CD31 as well as decreased the ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.