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. 2019 Jul 9;6(4):ENEURO.0140-19.2019. doi: 10.1523/ENEURO.0140-19.2019

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Copyright © 2019 Domínguez-Álvaro et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — A, Schematic representation of the shape of the synaptic junctions: macular synapses with continuous disk-shaped PSD; perforated synapses with holes in the PSD; horseshoe-shaped with tortuous horseshoe-shaped perimeter with an indentation; and fragmented synapses with two PSDs with no connections between them. B, Proportion of macular, perforated, horseshoe-shaped, and segmented AS and SS in control cases and AD patients. In AD patients, fragmented synapses were significantly more frequent than in control cases (χ², p < 0.001). C, Proportion of AS and SS belonging to each morphological category in control cases. The horseshoe-shaped synapses were significantly more frequent among SS than AS (χ², p < 0.0001). D, Proportion of AS and SS belonging to each morphological category in AD cases. *** p < 0.001.