Table 5.

Data regarding area (nm²), perimeter (nm), and curvature (ratio) of the SAS of macular, perforated, horseshoe-shaped, and fragmented synapses in control cases and AD patients

Group	Shape of synapses	Type of synapse	Area of SAS (nm2; mean ± SEM)	Perimeter of SAS (nm; mean ± SEM)	Curvature of SAS (mean ± SEM)
Control	Macular	AS	88,272 ± 1283	1352 ± 11	0.04 ± 0.001
		SS	70,960 ± 3764	1306 ± 40	0.05 ± 0.005
	Perforated	AS	264,960 ± 6606	2914 ± 58	0.07 ± 0.003
		SS	108,320 ± 22,066	2080 ± 279	0.07 ± 0.016
	Horseshoe-shaped	AS	262,251 ± 13,757	3725 ± 163	0.09 ± 0.007
		SS	88,466 ± 13204	1876 ± 153	0.06 ± 0.011
	Fragmented	AS	360,245 ± 34,068	3735 ± 435	0.14 ± 0.025
		SS	-	-	-
Alzheimer	Macular	AS	91,162 ± 1689	1367 ± 14	0.04 ± 0.001
		SS	59,436 ± 3156	1224 ± 42	0.06 ± 0.005
	Perforated	AS	259,540 ± 7942	2879 ± 73	0.07 ± 0.003
		SS	123,147 ± 14,857	1776 ± 129	0.03 ± 0.006
	Horseshoe-shaped	AS	237,778 ± 9524	3568 ± 127	0.08 ± 0.006
		SS	115,312 ± 0.0	2431 ± 0	0.07 ± 0.000
	Fragmented	AS	303,922 ± 21,783	2985 ± 210	0.13 ± 0.014
		SS	-	-	-

All data are corrected for shrinkage factor. SEM: standard error of the mean.