TABLE 1.

Relative abundances of select metabolite levels for which the ΔsrrAB and ΔclpC mutations are nonadditive^a

Metabolite	ΔclpC		ΔsrrAB		ΔsrrAB ΔclpC
	FC	P value	FC	P value	FC	P value
Acetate	1.6 ± 0.3	1.7E−03	1.4 ± 0.3	3.4E−02	1.7 ± 0.4	1.3E−03
ADP	1.9 ± 0.2	8.7E−05	1.8 ± 0.3	4.8E−04	1.6 ± 0.4	2.1E−03
Asparagine	1.2 ± 0.1	2.1E−04	1.5 ± 0.3	2.5E−03	1.3 ± 0.2	1.0E−02
Citrulline	1.3 ± 0.3	1.4E−01	1.4 ± 0.3	1.4E−02	0.7 ± 0.1	3.0E−03
Formate	1.4 ± 0.1	4.6E−05	1.2 ± 0.2	3.5E−02	1.2 ± 0.1	4.4E−03
Glutarate	0.5 ± 0.3	4.8E−02	2.4 ± 2.0	1.5E−02	0.9 ± 0.6	7.4E−01
GTP	0.8 ± 0.1	3.1E−02	1.4 ± 0.1	2.8E−05	0.5 ± 0.0	3.6E−06
Lactate	1.3 ± 0.1	7.3E−04	1.5 ± 0.3	1.6E−03	1.2 ± 0.3	2.0E−01
Lysine	1.2 ± 0.1	1.5E−02	1.3 ± 0.1	3.9E−03	1.2 ± 0.1	5.3E−03
Methionine	1.9 ± 0.2	6.5E−06	1.4 ± 0.2	1.1E−02	2.0 ± 0.4	2.7E−03
NAD	1.9 ± 0.2	2.1E−05	1.3 ± 0.2	1.4E−03	1.9 ± 0.2	4.2E−04
NADP	1.2 ± 0.3	3.4E−01	1.1 ± 0.3	4.9E−01	1.0 ± 0.2	8.5E−01
N-Alpha-acetyllysine	1.7 ± 0.6	3.6E−02	1.2 ± 1.0	5.8E−01	1.4 ± 1.1	1.9E−01
Niacinamide	1.7 ± 0.3	1.5E−03	1.2 ± 0.3	1.2E−01	1.6 ± 0.5	2.0E−02
Nicotinamide N-oxide	1.2 ± 0.1	1.7E−01	1.6 ± 0.7	2.9E−02	1.2 ± 0.3	2.0E−01
O-Phosphocholine	1.2 ± 0.3	1.7E−01	1.5 ± 0.5	3.0E−02	1.6 ± 0.5	1.1E−02
Phenylalanine	1.3 ± 0.1	6.4E−03	1.3 ± 0.2	6.3E−03	1.3 ± 0.2	5.2E−03
sn-Glycero-3-phosphocholine	1.6 ± 0.1	1.1E−03	1.3 ± 0.2	7.2E−03	1.1 ± 0.2	9.3E−02
Succinate	0.9 ± 0.0	2.6E−01	2.1 ± 0.9	1.7E−02	1.2 ± 0.5	3.3E−01
Theophylline	7.5 ± 0.7	2.5E−06	1.4 ± 0.6	3.5E−01	7.0 ± 1.9	3.2E−06
Threonine	1.3 ± 0.1	3.9E−03	1.5 ± 0.3	2.7E−03	1.2 ± 0.3	1.7E−01
Trigonelline	1.9 ± 0.7	1.5E−02	1.1 ± 1.3	8.9E−01	1.5 ± 1.1	1.1E−01
Tryptophan	1.3 ± 0.1	9.1E−03	1.2 ± 0.2	4.5E−02	1.3 ± 0.2	2.3E−03
Tyrosine	1.4 ± 0.1	5.9E−06	1.2 ± 0.2	3.6E−02	1.3 ± 0.2	2.3E−02
UMP	1.1 ± 0.1	1.1E−01	1.5 ± 0.3	2.7E−03	0.9 ± 0.2	1.5E−01

^aData presented as fold changes (FC) and significance (P values) relative to the WT.