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. 2019 Jul 3;10:737. doi: 10.3389/fphar.2019.00737

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Copyright © 2019 Ma, Liu, Liu, Wang, Chang, Li, Li, Hou and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioinformatics analyses for screening the key bioactive compound and predicting its target and signaling pathway. (A) The PPI analysis of the phosphorylated proteins related to the key node and function. (B) Molecular docking of PEI with EGFR; PyMOL software was used to display the 3D map of the interaction of PEI with EGFR (PDB:3W2S). (C) The bioinformatics pathway analysis was used to predict that the bioactive ingredient PEI acted on the EGFR signaling pathway.