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. 2019 Jul 4;9:613. doi: 10.3389/fonc.2019.00613

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Copyright © 2019 Pan, Zhan, Chen, Wu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Differences in mRNAsi between normal (19 samples) and tumor (404 samples) tissues. (B) Differentially expressed genes; blue indicates down-regulated of genes, and red indicates up-regulated of genes. (C) After primary treatment, the progression group had a higher corrected mRNAsi (mRNAsi/tumor purity) than the complete remission group. (D) Comparison of mRNAsi in five MIBC molecular subtypes. (E) Kaplan-Meier curves show that the low mRNAsi group had greater mortality than does the high mRNAsi group. (F) Excluding T1 and T4b with small sample size, mRNAsi generally decreases with bladder cancer progression. (G) Comparison of corrected mRNAsi in five MIBC molecular subtypes. (H) Kaplan–Meier curves show that the higher corrected mRNAsi group had greater mortality than that of the lower mRNAsi group. (I) Corrected mRNAsi generally increases from located to advanced.