Figure 1.

Renin contributes to the periodontal bone loss and inflammation response in normal and diabetic mice 14 days after PD. Histological sections of the lower first molars from the normal mice [control (A), normal with PD (C), normal with PD treated with aliskiren (Alisk) (E)], diabetic mice [control (B), diabetic with PD (D), and diabetic with PD and treated with Alisk (F)]. Percentage of alveolar bone area per μm² computed using Image J (G) software. C-reactive protein production by gingival fibroblast in normal and diabetic mice 14 days after PD (H). Data are represented as mean ± SEM (n = 10). Significant values are represented as ***p < 0.001 and *p < 0.05 (Control vs. PD; PD vs. Alisk + PD; and PD vs. PD+Alisk), and ^#p < 0.05 (diabetic + PD vs normal + PD).