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. 2019 Jul 4;10:708. doi: 10.3389/fphar.2019.00708

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Copyright © 2019 Oliveira, Brito, Frasnelli, Ribeiro, Ferreira, Queiroz, Beltan, Lara and Santos

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AGT, ACE, AT1R, AT2R, ACE2, and MasR gene expression of gingival tissue from normal and diabetic mice 14 days after PD. (A) AGT, (B) ACE, (C) AT1R, (D) AT2R, (E) ACE2, and (F) MasR in gingival tissue of control, normal mice with PD (PD), normal mice with PD treated with aliskiren (Alisk + PD), control, diabetic mice with PD (PD), diabetic mice with PD treated with aliskiren (Alisk + PD) by real-time RT-PCR. Results express mean ± SEM, normalized by fold change. Significant values are represented by *p < 0.001, **p < 0.05, ***p < 0.005, and ****p < 0.0001 (Control vs. PD, PD vs. Alisk+ PD, PD vs. PD, PD+Alisk vs. PD+Alisk).