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. 2019 Jul 4;10:708. doi: 10.3389/fphar.2019.00708

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Copyright © 2019 Oliveira, Brito, Frasnelli, Ribeiro, Ferreira, Queiroz, Beltan, Lara and Santos

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Col1a1, Col1a2, Col3a1, Fn1, and Tgfb1 gene expression of gingival tissue from normal and diabetic mice at 14 days after PD regardless of the fact if they were treated or not with aliskiren. (A) Col1a1, (B) Col1a2, (C) Col3a1, (D) Fn1, and (E) Tgfb1 in gingival tissue of control normal, normal with PD, normal with PD treated with aliskiren, control diabetic, diabetic with PD, and diabetic with PD treated with aliskiren by real-time RT-PCR. Results express mean ± SEM, normalized by fold change. Significant values are represented by p < 0.001, **p < 0.05, ***p < 0.005, and ****p < 0.0001 (Control vs. PD, PD vs. Alisk+PD, PD vs. PD, and PD+Alisk vs. PD+Alisk).