Fig. 1.

Glucocorticoid receptor knockout (GRKO) zebrafish are larger than wild type (WT), with different body composition. A: representative image of GRKO adult female zebrafish and a WT female zebrafish. B: the body mass of GRKO zebrafish, both male and female, was higher than that of their WT counterparts. C: however, the gonadosomatic index was not significantly different between the two groups. The GRKO fish consumed less food (D), had greater total protein content (E), higher total lipid content (F), and less moisture (G) compared with the WT controls. There was no change in carbohydrate levels, including whole body glucose (H) and glycogen contents (I). Values are means ± SE (n = 4–6). B, inset: main effect (two-way ANOVA; P < 0.05) is shown. *Significantly different from the WT (t-test; P < 0.05).