Fig. 10.

Expression of various inflammatory transcriptional regulatory factors is not altered by cytochrome P450 1B1 (Cyp1b1) expression. A: the expressions of Stat1, phospho (p)-Stat1, Stat3, p-Stat3, NF-κB p65 subunit (p65), p-p65, and cyclooxygenase-1 (Cox-1) were determined using lysates prepared from Cyp1b1^+/+ and Cyp1b1^−/− retinal astrocytes (ACs) by Western blot analysis using specific antibodies. β-Actin was used as a loading control. B: quantitative assessment of the data. Please note a significant decrease in the levels of Cox-1 in Cyp1b1^−/− ACs (**P < 0.01; n = 3).