Cytochrome P450 1B1 (Cyp1b1) deficiency does not affect protein kinase B (AKT)/SRC/MAPK signaling pathways in retinal astrocytes (ACs). A: the expression levels of Akt, phospho (p)-Akt, Erk1/2, p-Erk1/2, Src, p-Src, Jnk, p-Jnk, MAPK p38 (p38), and p-p38 were determined by Western blot analysis of lysates prepared from Cyp1b1+/+ and Cyp1b1−/− retinal ACs. β-Actin was used as a loading control. B: quantitative assessment of the data. Please note that no significant differences were observed between Cyp1b1+/+ and Cyp1b1−/− ACs.