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Elevated trypsin promoted the development of chronic pancreatitis. A: chronic pancreatitis was induced by repeated episodes (once a week for 2 wk) of acute pancreatitis with caerulein hyperstimulation (50 μg/kg ip hourly for 8 h). B: whole mount pancreas size (left) and relative pancreas weight (pancreas weight vs. body weight; right) comparisons. (*P < 0.001; n = 4 mice/group). C: representative pancreas histology of chronic pancreatitis in BAC and Try/BAC mice.
