Table 2.

Known protein expression profiles, functions, and disease contributions of Eph receptors and ephrin ligands on various immune cell subsets.

	Immune cell subsets
	Platelets	Monocytes and macrophages	Dendritic cells	B cells	T cells
Eph receptor protein expression	EphA4, EphB1, EphB2	EphA2, EphA4, EphB2, EphB4	EphA2, EphB1, EphB2, EphB3	EphA3, EphA4, EphA7, EphA10, EphB2, EphB6	EphA1, EphA3, EphA4, EphB3, EphB4, EphB6
Eph receptor functions	Platelet activation, thrombus formation	Cell spreading and adhesion, extravasation	Cell organization and trafficking	B cell activation, proliferation, and antibody production	IL-21 production in germinal centers, TCR signaling, T cell activation, migration, functionality
Cell-type specific disease relevance	EphB2 mutation associated with platelet dysfunction and/or recurrent bleeding in humans	Liver fibrosis, Arteriosclerosis	EphA2 serves as a herpesvirus entry receptor on DCs	EphA4 associated with B-cell lymphoma and post-transplant lymphoproliferative disorder	EphA3, EphB3 and EphB6 involved in T cell malignancies
Ephrin ligand protein expression	Ephrin-B1	Ephrin-A1, Ephrin-A2, Ephrin-A4, Ephrin-B2	Unknown	Ephrin-A1, Ephrin-A4, Ephrin-B1	Ephrin-A1, Ephrin-B1, Ephrin-B2, Ephrin-B3
Ephrin ligand functions	Thrombus stability	Cell-cell contact/adhesion	Unknown	Cell-cell contact/adhesion, germinal center interactions and organization	Thymocyte development, T cell differentiation, activation, costimulation, migration
Cell-type specific disease relevance	Unknown	Atherosclerotic plaque formation	Unknown	Relation to chronic lymphocytic leukemia progression	Contribution to rheumatoid arthritis pathogenesis, possible involvement in multiple sclerosis
References	(52–56)	(57–66)	(67–70)	(71–78)	(9, 78–92)