Fig. 5.

Nomogram to predict 5-year recurrence risk in meningiomas. (A) Total points generated from scoring of methylome-based RFS predictor, WHO grade, and Simpson grade are tallied in the calculator and correlated to 5-year RFS in the nomogram in the risk nomogram. (B) Time-dependent average AUC with 95% CI as well as ΔAUC (dAUC) with 95% CI using 10 000 bootstrap resampling validation approach generated for the meningioma recurrence score and a nomogram using clinical factors alone in the first and third validation cohorts as well as both combined validation cohorts. (C) Calibration curve of the nomogram to predict RFS at 5 years in the combined validation cohort. The observed RFS is plotted on the y-axis and nomogram predicted probability is plotted on the x-axis.