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. 2019 Jun 3;21(7):901–910. doi: 10.1093/neuonc/noz061

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Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Fig. 6 — The meningioma recurrence score identifies 2 risk groups (high risk vs low risk) that may help individualize adjuvant management decisions such as the need for radiation therapy in patients with meningiomas. Patient tumor samples can be interrogated for DNA methylation profile of selected 9529 probes, and a 5-year methylome-based RFS predictor score is generated. This score is combined with tumor WHO grade and Simpson grade in the meningioma recurrence score to develop an individualized probability of 5-year RFS.