Table 4.
Parameter estimates of the LMEMs for preoperative predictors of late cognitive performance (at T12) on CNS VS domains
| Verbal Memory | Visual Memory | Processing Speed | Psychomotor Speed | Reaction Time | Complex Attention | Cognitive Flexibility | |
|---|---|---|---|---|---|---|---|
| Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | |
| Interval T0-T3a | −0.22 (0.09) | 0.19 (0.09) | 0.22 (0.07) | 0.42 (0.08) | 0.33 (0.13) | 0.25 (0.15) | 0.21 (0.12) |
| Interval T3-T12a | 0.26 (0.13) | −0.10 (0.12) | 0.21 (0.07) | 0.01 (0.09) | 0.49 (0.18) | 0.49 (0.18) | 0.53 (0.10) |
| Months T0-T12b | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| Sociodemographic variables | |||||||
| Ageb | 0.01 (0.01) | 0.01 (0.01) | 0.01 (0.01) | −0.01 (0.01) | −0.02 (0.01) | −0.02 (0.01) | −0.00 (0.01) |
| Sexb | |||||||
| female (vs men) | 0.15 (0.20) | −0.46 (0.18) | −0.53 (0.15) | 0.05 (0.16) | 0.37 (0.30) | 0.05 (0.19) | 0.24 (0.14) |
| Educationb | |||||||
| middle (vs low) | −0.02 (0.20) | 0.16 (0.18) | 0.06 (0.16) | −0.21 (0.17) | 0.22 (0.31) | −0.06 (0.20) | 0.01 (0.14) |
| high (vs low) | 0.44 (0.21) | 0.08 (0.19) | −0.03 (0.17) | 0.53 (0.17) | 0.40 (0.33) | 0.41 (0.21) | −0.27 (0.15) |
| Clinical variables | |||||||
| Hemisphereb | |||||||
| right (vs left) | −0.08 (0.17) | −0.15 (0.15) | −0.14 (0.13) | −0.26 (0.14) | −0.14 (0.25) | 0.03 (0.16) | 0.20 (0.12) |
| Supratentorialb | |||||||
| yes (vs no) | 0.16 (0.29) | 0.50 (0.26) | −0.27 (0.23) | −0.37 (0.24) | 0.24 (0.45) | 0.13 (0.29) | −0.13 (0.21) |
| Frontalb | |||||||
| yes (vs no) | −0.11 (0.17) | −0.40 (0.16) | −0.19 (0.14) | −0.11 (0.14) | 0.13 (0.27) | 0.27 (0.17) | 0.03 (0.13) |
| Multipleb | |||||||
| yes (vs no) | 0.10 (0.35) | 0.41 (0.32) | 0.18 (0.28) | −0.48 (0.30) | 0.25 (0.54) | −0.01 (0.34) | 0.15 (0.25) |
| Volume mmbc | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| ASA scoreb | |||||||
| >3 (vs 1 or 2) | 0.43 (0.24) | −0.23 (0.22) | 0.07 (0.19) | −0.51 (0.20) | −0.11 (0.38) | −0.19 (0.24) | 0.36 (0.17) |
| Medicationbd | |||||||
| yes (vs no) | −0.06 (0.17) | −0.25 (0.15) | −0.24 (0.13) | 0.01 (0.14) | 0.03 (0.26) | −0.22 (0.17) | 0.21 (0.12) |
| Psychological variables | |||||||
| HADS Abe | 0.01 (0.02) | −0.05 (0.02) | −0.03 (0.02) | −0.04 (0.02) | 0.01 (0.04) | −0.01 (0.02) | −0.00 (0.02) |
| HADS Dbe | −0.01 (0.02) | 0.02 (0.02) | 0.03 (0.02) | 0.03 (0.02) | −0.04 (0.03) | 0.01 (0.02) | −0.01 (0.02) |
| Cognitive variables | |||||||
| Verbal Memoryb | − | 0.31 (0.06) | 0.04 (0.06) | 0.02 (0.06) | 0.09 (0.11) | 0.04 (0.07) | −0.07 (0.05) |
| Visual Memoryb | 0.40 (0.07) | — | −0.09 (0.06) | 0.05 (0.06) | 0.02 (0.12) | 0.07 (0.08) | 0.06 (0.06) |
| Processing Speedb | 0.01 (0.09) | −0.09 (0.08) | — | 0.34 (0.06) | 0.17 (0.14) | 0.05 (0.09) | 0.15 (0.07) |
| Psychomotor Speedb | 0.12 (0.08) | 0.09 (0.08) | 0.39 (0.05) | — | 0.18 (0.13) | −0.16 (0.08) | 0.05 (0.06) |
| Reaction Timeb | −0.01 (0.05) | −0.03 (0.04) | 0.01 (0.04) | 0.02 (0.04) | — | −0.04 (0.05) | 0.11 (0.03) |
| Complex Attentionb | 0.08 (0.09) | 0.05 (0.08) | 0.02 (0.07) | −0.10 (0.07) | −0.09 (0.13) | — | 0.59 (0.03) |
| Cognitive Flexibilityb | −0.08 (0.11) | 0.06 (0.10) | 0.18 (0.09) | 0.23 (0.09) | 0.44 (0.17) | 1.05 (0.05) | — |
a in bold: P < BH-corrected alpha .03.
b in bold: P < BH-corrected alpha .005.
c data missing for n = 6; d data missing for n = 6; e data missing for n = 7.
Estimates (B) are positive or negative depending on whether they are predicting higher (+) or lower (-) cognitive performance at T12.