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. 2019 Jul 4;11:172. doi: 10.3389/fnagi.2019.00172

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Copyright © 2019 Nizari, Carare, Romero and Hawkes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perivascular cholinergic contact at smooth muscle cells. (A–E) Representative images of the 3D reconstruction of the NVU in arteries in the hippocampus (A,B) and cortex (D,E) from control (A,D) and saporin-treated (B,E) mice. ChAT-positive nerve fibers are shown in red and smooth muscle cells are shown in green. (C,F) Quantification of the surface area of contact between ChAT-positive fibers and SMA demonstrated a significant decrease in contact in saporin-treated animals in both the hippocampus (C) and cortex (F). Data represent mean ± SEM. *p < 0.05, Mann-Whitney U test (hippocampus) and one-tailed Student’s t-test (cortex). Scale bars = 20 μm.