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Schematic of dual and divergent location-specific functions of caspase-3 (Casp 3). Cytoplasmic activation of caspase-3 promotes endothelial barrier integrity although the molecular targets are unknown and warrant further investigation. Nuclear translocation of caspase-3 promotes apoptosis and endothelial barrier disruption; the molecular mechanism by which caspase-3 translocates to the nucleus is still under investigation.
