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Effect of SERCA2a mutations on ER Ca2+ uptake. A: representative traces of ER Ca2+ uptake mediated by wild-type recombinant SERCA2a (WT) and 2 SERCA2a mutants (QNQ and AAA). Maximum [Ca]ER uptake rate (B) and maximum [Ca2+]ER load (C) mediated by WT (n = 20 cells), AAA (n = 13 cells), and QNQ (n = 10 cells) SERCA2a mutants. *P < 0.05 vs. WT.
