Table 3.
Echocardiogram data for male SS and SS-3BN rats treated with 24 Gy × 1 fraction of localized, image-guided irradiation
| Baseline |
3 mo |
6 mo |
||||
|---|---|---|---|---|---|---|
| SS | SS-3BN | SS | SS-3BN | SS | SS-3BN | |
| IVSd, cm/kg | 0.60 ± 0.04 | 0.71 ± 0.03 | 0.52 ± 0.04 | 0.63 ± 0.03 | 0.63 ± 0.03 | 0.56 ± 0.02 |
| LVIDd, cm/kg | 2.48 ± 0.14 | 2.80 ± 0.11 | 1.81 ± 0.04 | 1.89 ± 0.05 | 1.79 ± 0.07 | 1.97 ± 0.04* |
| LVIDs, cm/kg | 1.26 ± 0.11 | 1.44 ± 0.10 | 0.94 ± 0.06 | 0.55 ± 0.04† | 0.96 ± 0.07 | 0.90 ± 0.05 |
| LVPWd, cm/kg | 0.62 ± 0.03 | 0.70 ± 0.04 | 0.61 ± 0.03 | 0.65 ± 0.03 | 0.64 ± 0.04 | 0.61 ± 0.02 |
| EDV, ml/kg | 3.19 ± 0.37 | 3.15 ± 0.29 | 2.09 ± 0.11 | 1.84 ± 0.13 | 2.00 ± 0.17 | 2.20 ± 0.10 |
| ESV, ml/kg | 0.50 ± 0.09 | 0.50 ± 0.10 | 0.37 ± 0.06 | 0.07 ± 0.01† | 0.37 ± 0.07 | 0.26 ± 0.04 |
| SV, ml/kg | 2.70 ± 0.28 | 2.64 ± 0.21 | 1.72 ± 0.06 | 1.77 ± 0.12 | 1.63 ± 0.14 | 1.94 ± 0.08 |
| LVM, g/kg | 4.75 ± 0.25 | 5.15 ± 0.21 | 4.19 ± 0.14 | 4.19 ± 0.11 | 4.46 ± 0.25 | 4.13 ± 0.08 |
| FS, % | 49.27 ± 1.50 | 48.91 ± 2.37 | 48.73 ± 2.47 | 70.95 ± 1.82† | 46.87 ± 2.51 | 54.27 ± 1.97* |
| EF, % | 85.05 ± 1.27 | 84.66 ± 2.00 | 83.45 ± 1.99 | 96.77 ± 0.53† | 81.92 ± 2.67 | 88.50 ± 1.37* |
Values are means ± SE. EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; FS, fractional shortening; IVSd, interventricular septal wall thickness during diastole; LVIDd, left ventricular internal diameter at end diastole; LVIDs, left ventricular internal diameter at end systole; LVM, left ventricular mass; LVPWd, left ventricular posterior wall thickness at diastole; SS, Dahl salt-sensitive/Mcwi; SS-3BN, substitution of rat chromosome 3 from the resistant Brown Norway rat strain onto the SS background; SV, stroke volume.
*
P < 0.05;
†
P < 0.01.