Fig. 7.

Infiltration of effector CD8 T cells promotes a diverse proinflammatory infiltrate within nascent atherogenic foci. A: hyperlipidemic mice received transfer of wild-type (WT) or CD137^−/− Ova-specific CD8 T cells and were immunized with SIINFEKL and agonist anti-CD137 mAb. Thirty days postimmunization (dpi), aortic arches were analyzed by flow cytometry for infiltration of transferred CD8 T cells. B: percentage (gated on viable cells) and cell count of transferred CD8 per vessel are shown. ^nsP > 0.2, **P < 0.004 by 2-group t-test; n = 6–7 mice/group. C: immunohistofluoresence of the branch point of the right subclavian artery from the brachiocephalic artery 30 dpi shows intimal persistence of transferred CD8 T cells (CD45.1 in red) within atherogenic foci.