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. 2019 Mar 15;316(6):H1507–H1527. doi: 10.1152/ajpheart.00660.2018

Fig. 3.

Fig. 3.

The right ventricle (RV) and left ventricle (LV) local conduction delays in a representative calyculin experiment as a function of pacing cycle lengths (CL) and time of calyculin perfusion. A: conduction delay maps. Colors from dark violet to yellow indicate spatial distribution of local conduction delays in the range from 0 to 3.9 ms/mm. Columns (left to right) represent different time points (from 0 to 30 min). Rows (top to bottom) represent different pacing CLs (from 400 to 150 ms). White arrowhead indicates the site of pacing in the lateral LV. White line demarcates the RV and the LV. B: average RV (blue) and LV (red) conduction delay values computed for the maps shown in A. Symbols indicate values computed at different pacing CLs: circle (400 ms); square (300 ms); triangle (260 ms); diamond (230 ms); inverted triangle (200 ms); cross (170 ms); and tilted cross (150 ms). Different from Fig. 2, only 30 min of drug perfusion is shown, which was sufficient to achieve maximal effect. Calyculin decreased conduction delays (hence, increased conduction velocity) in both chambers, the effect being slightly larger in the RV.