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. 2019 Mar 15;316(6):H1507–H1527. doi: 10.1152/ajpheart.00660.2018

Fig. 8.

Fig. 8.

Effect of TTX alone and in combination with KN-93 on the right ventricle (RV) and the left ventricle (LV) conduction. A: conduction delay maps generated for LV paced activations at a cycle lengths (CL) of 400 ms (top) or 230 ms (bottom) in a representative experiment at baseline (left), after perfusion with TTX alone (middle), or after subsequent perfusion with TTX + KN93 (right). White arrowhead indicates the site of pacing in the lateral LV. White line demarcates the RV and the LV. B: changes in the mean chamber-specific normalized average delays for 3 hearts perfused initially with 1 μM TTX alone followed by a cocktail of 1 μM TTX and 2.75 μM KN93. Three-way ANOVA was used to assess the effect of intervention (no drug, TTX, and TTX + KN93), pacing CL (400 or 230 ms), and chamber (RV vs. LV). All factors exhibited significant contrasts (P < 0.0001) as determined by the statistical test. In addition, pairwise comparisons revealed significant differences (P < 0.05 by Newman-Keuls post hoc test) as labeled. *Significant differences between baseline and TTX comparing the same chamber and the same pacing CL. #Significant differences between TTX and TTX + KN93 comparing the same chamber and the same pacing CL. §Significant difference between the RV and the LV in the presence of TTX + KN93 at the CL of 230 ms. ‡Significant difference between the RV values at the CL of 400 vs. 230 ms in the presence of TTX + KN93.