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. 2019 Jul 4;10:645. doi: 10.3389/fgene.2019.00645

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Copyright © 2019 Chalertpet, Pin-on, Aporntewan, Patchsung, Ingrungruanglert, Israsena and Mutirangura

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between methylation levels and protein-binding sites. The Chi-square p-values are calculated from 2 × 2 contingency tables that count the number of methylation probes. The rows of a contingency table separate highly and lowly methylated probes, whereas the columns separate probes that are in proximity with protein-binding sites and probes that are not. Note that a single probe might be in proximity with multiple protein. (A) Only ChIP DNAs that are perfectly matched with the human genome are included. (B) Only ChIP DNAs that are approximately matched with the human genome are included. This also includes perfectly matched DNAs.