Table 2.

Similar side effects reported for both antipsychotics and antiepileptic drugs leading to potentially negative pharmacodynamic interactions.

Side effect	Antiepileptic drugs	Antipsychotics
Dizziness and falls	Almost all AEDs but less described with levetiracetam	Orthostatic hypotension with phenothiazines, clozapine, iloperidone, quetiapine, risperidone
Extrapyramidal symptoms	Valproate	All (less evident with aripiprazole and risperidone)
Liver dysfunction	Carbamazepine, phenytoin, felbamate, valproate	Steatosis with clozapine or olanzapine
Long QT	Felbamate	Amisulpride, haloperidol, iloperidone and ziprasidone
Osteopenia	Carbamazepine, oxcarbazepine, phenytoin, primidone, phenobarbital, valproate, topiramate	Amisulpride, paliperidone and risperidone through hyperprolactinaemia
Sedation	All, but less frequent with lacosamide, lamotrigine, felbamate	All, but less evident with haloperidol and risperidone
Sexual dysfunction	Carbamazepine, phenytoin, barbiturates, pregabalin, topiramate	All, but especially olanzapine, risperidone, clozapine, haloperidol and thioridazine
Weight gain	Valproate, carbamazepine, clobazam, pregabalin, gabapentin, perampanel	All, but less evident with haloperidol, aripiprazole, ziprasidone (clozapine, olanzapine and quetiapine may cause hyperlipidaemia directly, without weight gain)
White cell blood count changes	Carbamazepine (agranulocytosis) valproate (neutropenia)	Clozapine (agranulocytosis) Quetiapine (neutropenia)

AED, antiepileptic drug.