Schematic of the sSMLM experimental system. The fluorophores are excited, and the emitted light is collected by an objective lens and passing through the dichroic mirror, tube lens, mirror and an entrance slit sequentially. Then the light passes through a transmission grating to be split into zeroth-order and first-order light, which provide the spatial and spectral information, respectively, and then two imaging lenses. The inset illustrates the zeroth-order (spatial) and first-order (spectral) images captured by the EMCCD.