Table 1.
Composition and characterization of APO-loaded COS-NPs formulations
| Formulation code | COS concentration (% w/v) | TPP concentration (% w/v) | Particle size (nm) | PDI | ZP (mV) | DEE (%) | Mucin-binding efficiency (%) |
|---|---|---|---|---|---|---|---|
| F1 | 0.3 | 0.2 | 904.20±23.01 | 0.388±0.22 | +6.82±0.67 | 19.65±1.07 | 1.30±0.62 |
| F2 | 0.5 | 0.2 | 814.93±70.70 | 0.347±0.11 | +10.67±0.40 | 24.10±2.10 | 9.56±2.63 |
| F3 | 0.3 | 0.1 | 833.10±77.99 | 0.848±0.16 | +24.27±0.50 | 17.15±1.11 | 36.70±4.58 |
| F4 | 0.5 | 0.1 | 436.20±24.45 | 0.390±0.07 | +38.20±1.47 | 35.06±1.89 | 51.22±2.99 |
| F5 | 0.4 | 0.15 | 718.90±74.99 | 0.653±0.16 | +28.63±1.14 | 22.59±0.98 | 39.35±3.09 |
Notes: Each value represents the mean ± SD (n=3). Each formulation contains 8 mg APO.
Abbreviations: APO, apocynin; COS, chitosan oligosaccharide; DEE, drug entrapment efficiency; NPs, nanoparticles; PDI, polydispersity index; TPP, tripolyphosphate; ZP, zeta potential.