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Kinetic analysis of the release data of APO from COS-NPs (F4)
| Release phase | Zero order | First order | Higuchi model | Release mechanism | Korsmeyer-Peppas | Drug release mechanism | |
|---|---|---|---|---|---|---|---|
| Coefficient of determination (R2) | (R2) | Diffusional exponent (n) | |||||
| Burst release phase | 0.8326 | 0.8735 | 0.9851 | Diffusion | 0.9817 | 0.4256 | Fickian |
| Sustained release phase | 0.8859 | 0.8993 | 0.9073 | Diffusion | 0.9048 | 0.1011 | Fickian |
Abbreviations: APO, apocynin; COS, chitosan oligosaccharide; NPs, nanoparticles.
