Table 1.
Clinicopathological information for BR300 tissue microarray categorised according to compartmental CTSS scores. CTSS scores of 0 and 1 behaved similarly in terms of survival, as were patients with CTSS scores of 2 and 3. Patients were therefore stratified based on low CTSS (score of 0 and 1) or high CTSS (score of 2 and 3) expression. Differences between clinical information was evaluated based on high and low CTSS scores in either the epithelial and stromal compartments. Statistical significance determined by Chi-Square test. Figure in brackets indicates percentage of total. LVI=lymphovascular invasion. N=number of patients.
| BR300 Cohort | CTSS Epithelial | CTSS Stromal | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N (%) | Low (%) | High (%) | p-value | N (%) | Low (%) | High (%) | p-value | ||
| Characteristic | 267 (100) | 221 (100) | 46 (100) | 262 (100) | 79 (100) | 183 (100) | |||
|
| |||||||||
| Age | N≤51 | 140 (52) | 113 (51) | 27 (59) | 140 (53) | 41 (52) | 99 (54) | ||
| Median = 51 | N>51 | 127 (48) | 108 (49) | 19 (41) | 0.42 | 122 (47) | 38 (48) | 84 (46) | 0.79 |
|
| |||||||||
| Grade | 1 | 4 (1) | 4 (2) | 0 (0) | 4 (2) | 3 (4) | 1 (1) | ||
| 2 | 106 (40) | 99 (45) | 7 (15) | 103 (39) | 45 (57) | 58 (32) | |||
| 3 | 157 (59) | 118 (53) | 39 (85) | 0.0004∗∗∗ | 155 (59) | 31 (39) | 124 (68) | <0.0001∗∗∗ | |
|
| |||||||||
| Tumour | 1 | 54 (20) | 45 (20) | 9 (20) | 54 (21) | 14 (18) | 40 (22) | ||
| 2 | 171 (64) | 146 (66) | 25 (54) | 166 (63) | 52 (66) | 114 (62) | |||
| 3 | 36 (13) | 24 (11) | 12 (26) | 36 (14) | 11 (14) | 25 (14) | |||
| 4/4b | 6 (2) | 6 (3) | 0 (0) | 0.035∗ | 6 (2) | 2 (3) | 4 (2) | 0.9 | |
|
| |||||||||
| Node | 0 | 114 (43) | 86 (39) | 28 (61) | 113 (43) | 33 (42) | 80 (44) | ||
| 1 | 93 (35) | 83 (38) | 14 (30) | 91 (35) | 26 (33) | 64 (35) | |||
| 2 | 34 (13) | 31 (14) | 3 (7) | 33 (13) | 13 (16) | 20 (11) | |||
| 3 | 26 (10) | 25 (11) | 1 (2) | 0.020∗ | 26 (10) | 7 (9) | 19 (10) | 0.66 | |
|
| |||||||||
| LVI | Yes | 168 (63) | 145 (66) | 23 (50) | 164 (63) | 51 (65) | 113 (62) | ||
| No | 96 (36) | 73 (33) | 23 (50) | 96 (37) | 26 (33) | 70 (38) | |||
| Unknown | 3 (1) | 3 (1) | 0 (0) | 0.076 | 3 (1) | 2 (3) | 1 (1) | 0.3 | |
|
| |||||||||
| Histology | Ductal | 210 (79) | 172 (78) | 38 (83) | 207 (79) | 49 (62) | 158 (86) | ||
| Lobular | 27 (10) | 24 (11) | 3 (7) | 26 (10) | 16 (20) | 10 (5) | |||
| Mixed | 24 (9) | 21 (10) | 3 (7) | 23 (9) | 12 (15) | 11 (6) | |||
| Other | 6 (2) | 4 (2) | 2 (4) | 0.52 | 6 (2) | 2 (3) | 4 (2) | <0.0001∗∗∗ | |
|
| |||||||||
| Radiotherapy | Yes | 220 (82) | 182 (82) | 38 (83) | 215 (82) | 70 (89) | 145 (79) | ||
| No | 47 (18) | 39 (18) | 8 (17) | 1.00 | 47 (18) | 9 (11) | 38 (21) | 0.080 | |
|
| |||||||||
| Hormone | Yes | 157 (59) | 147 (67) | 10 (22) | 157 (60) | 65 (82) | 88 (48) | ||
| Therapy | No | 110 (41) | 74 (33) | 36 (78) | <0.0001∗∗∗ | 109 (42) | 14 (18) | 95 (52) | <0.0001∗∗∗ |