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Central EX4 reduction in food-reward behavior is mediated via GLP-1Rs as pretreatment with a selective GLP-1R antagonist, EX3, abolishes the suppressive effect of EX4 on PR operant conditioning. ***p < 0.0005 comparing vehicle to EX4 using the Tukey test after detecting a significant interaction of pretreatment with EX4 in two-way ANOVA and a main effect of one-way ANOVA; n = 8. Data represent mean ± SEM.
