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VTA and NAc GLP-1R activation effects on 24 h chow intake and body weight. VTA GLP-1R activation potently reduced chow intake (A) and body weight gain (B). In contrast, NAc shell GLP-1 activation produced a small reduction in 24 h chow intake (C) and did note alter body weight gain (D). ***p < 0.0005 comparing vehicle to each EX4 dose using the Tukey test after detecting a significant main effect of one-way ANOVA for each time point; n = 15. Data represent mean ± SEM.
