Figure 5.

The LV component of I_Prl is mediated by a Na⁺-dominated MCC. A, Voltage-clamp recording of an oscillating TIDA neuron in the presence of TTX and zero-Na⁺ recording solution. Application of Prl induced an inward current that was significantly reduced when compared with control. To the right, sharing its y-axis with the raw trace, are Gaussian fits of averaged (solid lines) holding current frequency distributions in control (green) and Prl (red). Raw data used to produce averages shown as dashed lines (n = 5). B, Voltage-clamp recording of an oscillating TIDA neuron in the presence of TTX and low-Ca²⁺/high-Mg²⁺ recording solution. Application of Prl induced an inward current that was significantly enhanced when compared with control. To the right, sharing its y-axis with the raw trace, are Gaussian fits of averaged (solid lines) holding current frequency distributions in control (green) and Prl (red). Raw data used to produce averages shown as dashed lines (n = 7). *p < 0.05, **p < 0.01.