. 2012 Jun 20;32(25):8663–8677. doi: 10.1523/JNEUROSCI.1107-12.2012

Table 1.

Cell-intrinsic measures of neuronal excitability in cortical layer II/III of WT and CKO mice

Parameter	Mean ± SD		p Value
Parameter	WT	ERK CKO	p Value
Input resistance (MΩ)	126 ± 73	125 ± 102	0.61
Membrane resistance (MΩ)	222 ± 96	192 ± 86	0.031^a
Membrane tau (ms)	9.5 ± 4.5	11.3 ± 3.4	0.005^a
Membrane capacitance (pF)	43 ± 13	42 ± 13	0.38
Spike threshold (mV)	−32 ± 9.1	−30.0 ± 4.8	0.12
Resting potential (mV)	−67 ± 14	−70 ± 7.0	0.11
Area of mean up-state (mV · s)	1.3 ± 0.52	1.49 ± 0.49	0.13

Comparison of WT and CKO mice showing that deletion of ERK2 led to a significant reduction in membrane resistance and a significant increase in the membrane time constant, while leaving input resistance, membrane capacitance, AP threshold, and resting potential unchanged.

^aStatistically significant.