Figure 6.

Peak-to-peak amplitudes of ABR waves are not reduced in BDNF^Pax2 KO mice following noise exposure. ABR waves illustrate the difference in signal amplitude in control (A) and BDNF^Pax2 KO mice (B) before and 7 d after trauma (AT; ±SEM), shown for stimulation with clicks presented at 20 dB above the hearing threshold. C, Peak to peak amplitudes at 20 dB above hearing threshold for five selected peak-to-peak amplitudes (wave I-V, arrows in D, two-way ANOVA: p < 0.001). After exposure the amplitude of control mice was significantly reduced for waves II-V compared with pre-exposure (two-way ANOVA: p < 0.05). Amplitudes of BDNF^Pax2 KO mice were not significantly decreased after exposure. Control, n = 8/16 mice/ears; BDNF^Pax2 KO, n = 8/16.