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. 2012 Jan 11;32(2):436–451. doi: 10.1523/JNEUROSCI.4831-11.2012

Figure 1.

Figure 1.

Heterozygous Nurr1 deficiency modulates peripheral maternal cytokine levels at basal conditions and following viral-like immune activation. A, The bar plots show serum levels of the prototypical proinflammatory cytokines IL-6 and TNFα and the antiinflammatory cytokine IL-10 in pregnant wt and Nurr1+/− mice treated with vehicle [saline (SAL)] or the viral mimetic poly(I:C) (POL) (2 mg/kg, i.v.) on gestation day 17. *p < 0.05 and **p < 0.01, based on post hoc group comparisons. Serum levels of IL-1β were below detection limit (0.3 pg/ml) for each experimental condition. B, The bar plots depict the balance between maternal proinflammatory versus antiinflammatory cytokines in terms of the IL-6/IL-10 and TNFα/IL-10 ratios in SAL- or POL-treated wt and Nurr1+/− dams. *p < 0.05, based on post hoc group comparisons. N(wt, SAL) = 4, N(wt, POL) = 4, N(Nurr1+/−, SAL) = 5, N(Nurr1+/−, POL) = 5. All values are means ± SEM.