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. 2012 Aug 15;32(33):11309–11317. doi: 10.1523/JNEUROSCI.1333-12.2012

Figure 1.

Figure 1.

A, CREB expression in CREB mutant mouse line. The photomicrographs show nuclear CREB immunoreactivity (black nuclei, red arrowhead) in GnRH neurons (brown cytoplasm, yellow arrowhead) in CREBloxP/loxP mouse and lack of CREB expression in GnRH neurons (brown cytoplasm, yellow arrowhead) in GnRH-CREB KO mouse. Scale bars, 10 μm. B, Histogram shows the percentage of GnRH neurons expressing CREB in control (C57BL/6, CREBloxP/loxP, CREM+/+), GnRH-CREB KO, global-CREM KO, and GnRH-CREB KO/global-CREM KO mice. The histogram shows the means (+SEM); n = 7–14. ***p < 0.001 (ANOVA with Tukey's post hoc test).