Table 3.
Brain activation associated with the main effect of stress and levels of cortisol
| Brain region | Hemisphere | BA | Peak t value | Coordinates (x, y, z) (MNI152) |
|---|---|---|---|---|
| Main effect of stress: stress versus control groups | ||||
| Posterior visual cortex | R | 18 | 4.92 | 12, −98, −8 |
| R | 17 | 4.37 | 10, −92, 6 | |
| dACC and mCC | R | 32 | 4.24 | 6, 10, 40 |
| — | 6 | 4.52 | 0, −10, 58 | |
| Striatum | R | — | 3.94 | 24, 4, 0 |
| Insula | R | 22 | 3.91 | 54, 16, 0 |
| 3.62 | 48, 2, 2 | |||
| Positive correlation of brain activity with levels of cortisol in the stress group | ||||
| Thalamus | R | — | 7.07 | 22, −18, 14 |
| L | 4.74 | −16, −12, 10 | ||
| Insula | R | 13 | 6.99 | 34, −18, 4 |
| L | 5.48 | −34, 0, 12 | ||
| mCC | R | 24 | 6.97 | 6, −10, 54 |
| L | 5.89 | −14, −12, 42 | ||
| Striatum | L | — | 4.90 | −22, 10, 10 |
| Posterior visual cortices | R | 18 | 4.89 | 22, −72, −16 |
| L | 19 | 4.53 | −36, −70, −18 | |
Only clusters significant at p < 0.05, corrected at the cluster level, are reported. dACC, Dorsoal anterior cingulate cortex; mCC, middle cingulate cortex; L, left; R, right; BA, Brodmann area; MNI152, Montreal Neurological Institute 152 stereotactic space.