Table 5.
Brain regions with significant group effects in the nodal efficiency among the control, aMCI, and RGD groups
| Regions | Category | F value (p value) of ANCOVA |
T value (p value) of post hoc test |
||
|---|---|---|---|---|---|
| Control versus aMCI | Control versus RGD | aMCI versus RGD | |||
| SFGmed.L | Frontal | 6.18 (0.003) | −2.04 (0.045) | −3.27 (0.002) | NS |
| SFGdor.L | Frontal | 5.26 (0.007) | −2.77 (0.007) | −2.78 (0.007) | NS |
| MFG.L | Frontal | 4.85 (0.010) | −2.77 (0.007) | −2.39 (0.020) | NS |
| ACG.L | Paralimbic | 4.26 (0.017) | −2.21 (0.031) | −2.82 (0.006) | NS |
| SFGdor.R | Frontal | 3.42 (0.037) | −2.48 (0.016) | −2.08 (0.042) | NS |
| ANG.L | Parietal | 3.38 (0.038) | −2.55 (0.013) | NS | NS |
| IFGtriang.L | Frontal | 3.38 (0.038) | −3.01 (0.004) | NS | NS |
| PCG.R | Paralimbic | 3.37 (0.039) | NS | NS | 2.30 (0.025) |
| PreCG.L | Frontal | 3.36 (0.039) | −2.17 (0.034) | −2.29 (0.025) | NS |
| MFG.R | Frontal | 3.33 (0.040) | −2.64 (0.010) | NS | NS |
| ANG.R | Parietal | 3.18 (0.046) | −2.27 (0.026) | NS | NS |
The FN-weighted WM network for each participant was constructed using an AAL template. The comparisons of nodal efficiency were performed among the three groups (aMCI, RGD, and controls) using univariate ANCOVAs. Post hoc pairwise comparisons were then performed using t test. The age, gender, and education effects were removed in all of these analyses. For ANCOVAs of the 90 brain regions, p < 0.05 (uncorrected) was considered significant. For post hoc tests, p < 0.05 was considered significant. NS, Not significant. For T values, each negative column represents aMCI < control, RGD < control, and RGD < aMCI, respectively.