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. 2019 Jul 4;9:602. doi: 10.3389/fonc.2019.00602

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Copyright © 2019 Yu, Wang, Kaul, Wadhwa and Miyako.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective cellular uptake of FRi-ExNC by FR-α-positive cancer cells. (A) Immunostaining for FR-α shows cellular membrane and cytoplasm distribution of FR-α, and higher expression in HeLa cells. Nucleus was stained with Hoechst. (B) Fluorescence microscopy imaging of HeLa and MCF7 cells incubated with i-ExNC and FRi-ExNC (labeled with Nile Red) for 6 h. FRi-ExNC was more efficiently internalized by HeLa (FR+) cells. (C) Quantitative cellular uptake amount of i-ExNC and FRi-ExNC in HeLa and MCF7 cells after 6 h incubation (mean ± s.e.m., n = 3), ^**P <0.01 (Student's t-test). FRi-ExNC incubation showed increase in i-Ex uptake by HeLa (FR+) cells, but not MCF7 (FR-) cells.