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. 2012 Sep 5;32(36):12579–12588. doi: 10.1523/JNEUROSCI.1267-12.2012

Figure 5.

Figure 5.

An interfering peptide that mimics the Src consensus sequence of Panx1 attenuates the AD. A, Mean ± SEM traces of the anoxic depolarization comparing the TAT peptide alone (10 μm intracellular; left trace), bath-applied TAT-Panx305–318 (10 μm; middle trace), and TAT-Panx305–318 (1 μm; right trace) in the patch pipette. Inclusion of TAT-Panx305–318 either in the bath or the patch pipette promoted recovery of the AD current toward baseline (dashed line). B, Quantitative analyses of the initial depolarization and residual current with and without inhibition presence of TAT-Panx1305–318 compared with the TAT peptide alone. C, Net cumulative charge transfer in the presence of TAT-Panx305–318 in the bath or pipette. Error bars are SEM. *p < 0.05, significant difference versus the TAT(i) group (paired t test).