Table 1.
Metabolic changes induced by sleep deprivation and cell stimulation
| Metabolite | Pathway | Change | META_Pval | META_Padj |
|---|---|---|---|---|
| Lactate | Glycolysis, gluconeogenesis, pyruvate metabolism | Up | 0.0014 | 0.0437 |
| Pantothenate | Pantothenate and CoA metabolism | Down | 0.0002 | 0.0264 |
| 5-Methylthioadenosine | Polyamine metabolism | Down | 0.0022 | 0.0437 |
| N-acetyl-aspartyl-glutamate | Glutamate metabolism | Down | 0.0044 | 0.0515 |
| N-acetylmethionine | Cysteine, methionine, S-adenosyl methionine, taurine metabolism | Up | 0.0045 | 0.0515 |
| Laurate (12:0) | Medium-chain fatty acid | Down | 0.0026 | 0.0437 |
| 1-Stearoylglycerol (1-monostearin) | Monoacylglycerol | Up | 0.0020 | 0.0437 |
| 1-Palmitoylglycerophosphocholine | Lysolipid | Up | 0.0025 | 0.0437 |
| 1-Palmitoylglycerophosphoinositol | Lysolipid | Up | 0.0026 | 0.0437 |
| 1-Linoleoylglycerophosphocholine | Lysolipid | Up | 0.0027 | 0.0437 |
| 1-Oleoylglycerophosphocholine | Lysolipid | Up | 0.0032 | 0.0463 |
| 1-Stearoylglycerophosphocholine | Lysolipid | Up | 0.0046 | 0.0515 |
| 1-Stearoylglycerophosphoethanolamine | Lysolipid | Up | 0.0075 | 0.0725 |
| 1-Palmitoleoylglycerophosphocholine | Lysolipid | Up | 0.0091 | 0.0757 |
| 1-Stearoylglycerophosphoinositol | Lysolipid | Up | 0.0092 | 0.0757 |
| 1-Myristoylglycerophosphocholine | Lysolipid | Up | 0.0094 | 0.0757 |
| 2-Palmitoleoylglycerophosphoethanolamine | Lysolipid | Up | 0.0135 | 0.0991 |
| 2-Oleoylglycerophosphocholine | Lysolipid | Up | 0.0137 | 0.0991 |
| γ-Glutamylleucine | γ-Glutamyl | Down | 0.0024 | 0.0437 |
| γ-Glutamylglutamine | γ-Glutamyl | Down | 0.0050 | 0.0515 |
Upregulated and downregulated metabolites identified by meta-analysis of global metabolomics of the cortex and primary cortical cultures. For detailed analysis, see Materials and Methods. META_Pval indicates p value after meta-analysis; META_Padj indicates the adjusted p value for multiple testing.