Figure 3.

MMP8 depletion protects from BCSFB leakage after systemic inflammation. Visualization of BCSFB leakage (red) (a) before and after endotoxemia in MMP8^+/+ mice (b) and MMP8^−/− mice (c); the inset displays nuclear staining (blue) of the CP and the surrounding brain tissue by confocal microscopy. d, MMP8 mRNA expression in the CP before and 4 h after LPS challenge (n = 5–8). e, Confocal images of MMP8 (red) immunofluorescence after LPS challenge in the epithelial CP cells and ependymal cells.