Figure 4.
A, Aβ42 reduced K+-evoked Ca+2 influx, indicating dead, dying, or dysfunctional cells, and PTI-125 attenuated this Aβ42-induced deleterious effect. n = 7 or 8. *p < 0.01 vs sham, vehicle; #p < 0.01 vs Aβ42, vehicle; ++p < 0.05 vs vehicle-treated and PTI-125-treated sham groups. B, Similarly, PTI-125 incubation partially normalized the drastic reduction in depolarization-induced calcium influx in postmortem AD or Aβ42-treated control tissue. n = 11. *p < 0.01 vs vehicle-treated control; #p < 0.01 vs vehicle-treated AD group; +p < 0.01 vs vehicle-treated and PTI-125-treated control groups.