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PTI-125 treatment of ICV Aβ42-infused mice nearly abolished Aβ42-induced production of inflammatory cytokines IL-6, TNF-α, and IL-1β in parietal cortex, measured by a fluorescence ELISA assay. n = 7 or 8. *p < 0.01 vs respective cytokine level in sham, vehicle group; #p < 0.01 vs respective cytokine level in ICV Aβ42, vehicle group.
