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. 2012 Jul 18;32(29):9773–9784. doi: 10.1523/JNEUROSCI.0354-12.2012

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Copyright © 2012 the authors 0270-6474/12/329773-12$15.00/0

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Figure 8. — A, Representative sections immunostained with an anti-NFT (phospho-tau) antibody show that PTI-125 treatment dramatically reduced NFT immunoreactivity in both prefrontal cortex and hippocampus of mice receiving ICV Aβ₄₂ infusions. B, Representative sections immunostained for Aβ₄₂ aggregates show that PTI-125 treatment greatly reduced Aβ₄₂ deposits in both brain regions of Aβ₄₂-infused mice. Immunostaining was quantified by image analysis software. n = 7 or 8. *p < 0.01 vs sham, vehicle; ^#p < 0.01 vs Aβ₄₂, vehicle.