Figure 2.

Reproduction of STDP experiments in vitro. Data shown in gray have been used to fit the mSTDP model parameters for STDP and short-term interactions (with the slow variables set to 0). A, Typical biexponential STDP curve, linking the relative amplitude of the synaptic change (positive for LTP, negative for LTD) with the t_post − t_pre interval and obtained with a simulated pairing protocol. Gray error bars in the graph are taken from Wang et al. (2005) recorded in hippocampal neurons for δt = ±10 ms. B, Relative synaptic changes induced by triplet protocols (denoted Tri) compared with experimental data obtained by Wang et al. (2005) (top, pre–post–pre; bottom, post–pre–post). Gray bars correspond to the original recordings for each protocol in the abscissa (with time intervals between each spike). Black bars correspond to the prediction of the model. The last set of columns represents the condition in which L-type calcium channels are blocked with nimo, a specific L-type calcium channel antagonist. C, STDP dependence on the pairing frequency for δt = ±10 ms. In gray are original data obtained for visual cortex neurons by Sjöström et al. (2001) for this protocol.