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. 2012 Jan 4;32(1):254–263. doi: 10.1523/JNEUROSCI.3701-11.2012

Table 3.

Brain regions showing glucose metabolism differences when comparing CTRL, ANX, and FEAR subgroups (n = 5 per subgroup) and correlations between glucose metabolism and behavioral measures

Cluster level
 Voxel level
 Coordinates of peak voxel
 Cluster comprising
pcorr kE T puncorr x y z
ANX > CTRL
    0.001 2270 6.10 <0.001 0.0 0.2 −7.4 Bed nucleus of the stria terminalis (mainly medial and lateral division), nucleus accumbens (core and shell), medial and lateral septal nucleus, and medial and lateral preoptic area
ANX < CTRL
    <0.001 3055 8.97 <0.001 −5.0 −3.4 −4.0 L primary somatosensory cortex (barrel field, upper lip, forelimb and hindlimb, shoulder and trunk regions) and L hippocampus (field CA1 and CA2)
    <0.001 4382 7.86 <0.001 5.0 −3.4 −4.2 R primary somatosensory cortex (barrel field, upper lip, forelimb and hindlimb, shoulder and trunk regions)
ANX > FEAR
    0.301 577 4.75 <0.001 −2.0 −1.0 −8.6 Bed nucleus of the stria terminalis (mainly medial and lateral division), nucleus accumbens (core and shell), medial and lateral septal nucleus, and medial and lateral preoptic area
ANX < FEAR
    0.659 338 4.22 0.001 3.6 −0.8 −2.6 R primary somatosensory cortex (mainly forelimb, shoulder, and trunk regions)
Negative correlation with freezing during acclimation on posttest in the ANX subgroup
    <0.001 211 35.87 <0.001 5.8 0.6 −3.4 R primary somatosensory cortex (mainly upper lip region)
Positive correlation with exploring during acclimation on posttest in the ANX subgroup
    <0.001 265 34.09 <0.001 −6.0 −1.4 −3.6 L primary somatosensory cortex (mainly barrel field, upper lip, and forelimb regions)

The x-coordinate corresponds to the distance (in millimeters) lateral to midline (right is positive), the y-coordinate indicates the position relative to bregma (anterior is positive), and the z-coordinate denotes the dorsoventral position. pcorr, cluster-corrected p value; kE, cluster extent (voxels); T, peak voxel t statistic; puncorr, uncorrected height p value. All (de)activated brain regions are bilateral, unless stated otherwise (L, left; R, right).