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Loss of Rb upregulates genes associated with cell cycle function. A, Heat map representing top 200 genes significantly upregulated by microarray upon acute Rb deletion (fold increase of ≥1.5, FDR <5%, n = 3). B, Gene functional classification of upregulated transcripts following Rb loss. C, qRT-PCR validation of targets identified by microarray analysis. D, Analysis of distribution of cell cycle regulatory genes induced upon Rb deletion. Error bars indicate SEM.
